What does it mean?
Several different sensors that are used in several different systems use a 5 volt reference voltage from the ECM to measure/monitor their systems. Some examples of these sensors are: A/C pressure sensor, MAP sensor , Camshaft position sensor, Crankshaft position sensor etc … This will vary between manufacturers so you will have to identify what systems use reference voltage in your particular vehicle model. These sensors work in conjunction with the ECM.
The ECM sends out a reference voltage to sensor which sends back a value to the ECM which then compares the values to measure/monitor given sensor. It converts this value and interprets it to use for engine performance. Refer to service manual for help identifying systems involved. Keep in mind that your vehicle uses 12v as a power supply. Testing a 5 volt circuit by powering up a circuit is a bad idea.
If you do not have at least basic understanding of how a 5 volt system works, i suggest you bring vehicle to reputable repair facility. This may be beyond your scope of knowledge.